Background: The COVID-19 is a pandemic viral infection with a high morbidity rate, leading to many worldwide deaths since the end of 2019.The RBD (Receptor Binding Domain) of SARS-CoV-2 through its spike utilizes several host molecules to enter host cells.One of the most important ones is the angiotensin-converting enzyme 2 (ACE2), an enzyme normal
There is still no ideal predictive biomarker for immunotherapy response among patients with non-small cell lung cancer.Costimulatory molecules play a role in anti-tumor immune response.Hence, they can be a potential biomarker for immunotherapy response.The current study comprehensively investigated the expression of costimulatory molecules in lung
In the limb bud, patterning along the anterior-posterior (A-P) axis is controlled by Sonic Hedgehog (Shh), a signaling molecule secreted by the "Zone of Polarizing Activity", an organizer tissue located in the posterior margin of the limb bud.We have found that the transcription factors GATA4 and GATA6, which are key regulators of cell identity, ar
Investment and construction activity development entailed not only the improvement of existing systems and approaches to the assessment of the state of participants of this process, but also the emergence of new areas of analysis based on a comprehensive space-oriented structure of both the project itself and its environment.The methods of the comp